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Funded Projects

2018

Clinical implementation of advanced MRI methods.
Eric Ahrens, UCSD / Petter Veiby, Takeda

A Treg cell-intrinsic CTLA4-PKC-eta signaling pathway mediating contact-dependent suppression of tumor immunity: A novel target for cancer immunotherapy.
Amnon Altman, La Jolla Institute for Immunology / Michael Shaw, Takeda

Rapid 3D Bioprinting of iPSC-derived Mature Cardiac Models for High Throughput Drug Screening.
Shaochen Chen, UCSD / Kenichi Imahashi, Takeda

Studying mechanisms of SSRI resistance with Major depressive disorder patient induced
pluripotent stem cell-derived neurons in vitro.
Fred Gage, Salk Institute / Yoshirou Tomimatsu, Takeda

Studying neuroinflammation relevant mechanisms of SSRI resistance in MDD patient iPS derived astrocytes in vitro.
Fred Gage, Salk Institute / Koji Nakamura, Takeda

Stem-cell based approaches to develop gut barrier-protective therapies in IBD.
Pradipta Ghosh, UCSD / Ewan Taylor, Takeda

Human iPSC-derived macrophages as a novel source for repair of liver fibrosis.
Dan Kaufman, UCSD / Andrea Fanjul, Takeda

A drug-screening platform for Autism Spectrum Disorders (ASD).
Alysson Muotri, UCSD / Inigo Narvaiza, Takeda

Molecular strategies to combat T cell exhaustion.
Anjana Rao, La Jolla Institute for Immunology / Gary Shapiro, Takeda

Characterization of human enteric nervous system stem cells for autologous therapy.
Gene Yeo, UCSD / Alan Burns, Takeda

2017

Bioprinting of iPSC-derived Cardiac Tissues for High-throughput Human Translatable Screening
Shaochen Chen, UCSD/Kenichi Imahashi, Takeda

2016

Translation of new imaging probe to track stem cells using MRI.
Eric Ahrens, UCSD/Shota Ikeda, Takeda 

New materials and methods to instruct hematopoietic stem cell fate from human pluripotent precursors.
David Traver and Karl Willert, UCSD/Yoji Ueda, Takeda

Studying cortical, hippocampal and serotonergic neurotransmission in neurons derived from patients with treatment resistant Major Depressive Disorder.
Rusty Gage, Salk/Keisuke Hirai, Takeda

Developing new repurposed drugs for Niemann Pick Type C1 and Alzheimer’s Disease.
Larry Goldstein, UCSD/Atsuko Suzuki, Takeda

Integration of single-cell RNA-sequencing and bacTRAP technology to identify and profile novel cell types in the gastrointestinal tract.
Gene Yeo, UCSD/Jill Wykosky, Takeda